Treatment monitoring and identification of molecular disease mechanisms may be facilitated by this biomarker.
2.
This discovery of what Pauling came to call a " molecular disease " was revolutionary.
3.
This was the first molecular disease characterized.
4.
The molecular disease concept put forward in the 1949 paper also became the basis for Linus Pauling's view of evolution.
5.
The paper introduced the concept of a " molecular disease ", and is considered a major impetus to the development of molecular medicine.
6.
His discovery of sickle cell anemia as a " molecular disease " opened the way toward examining genetically acquired mutations at a molecular level.
7.
Since the early 1990s, a new class of molecular disease has been characterized based upon the presence of unstable and abnormal expansions of DNA-triplets ( trinucleotides ).
8.
In November 1949, Pauling, Harvey Itano, S . J . Singer and Ibert Wells published " Sickle Cell Anemia, a Molecular Disease " in the journal " Science ".
9.
As WHIM syndrome is a molecular disease arising from gain-of-function mutations in CXCR4, preclinical studies identified plerixafor, a specific CXCR4 antagonist, as a potential mechanism-based therapeutic for the disease.
10.
He also advocated eugenic policies, such as marking all who carry the sickle cell trait and other molecular disease genes, to reduce the number of children born with genetic diseases.
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